ELI LILLY`S SIDNEY 블랙토토: `TAILORED THERAPEUTICS` ? THE PHARMACEUTICAL INDUSTRY`S NEXT BLOCKBUSTER?
From Knowledge at Wharton
As Sidney 블랙토토 prepares to retire as chairman and CEO of Eli Lilly, he predicts that significant changes at all levels of the health care industry will affect doctors, payers and patients alike. "I believe that the years ahead will amount to revolution much more than evolution," 블랙토토 says.
"It will not happen overnight, but we are already moving toward the barricades and headed toward a new business model," 블랙토토 says. Headquartered in Indianapolis, Ind., Eli Lilly has approximately 40,600 employees and more than $18.6 billion in sales. The company's top-selling drugs include Prozac, Cialis, Evista and Darvocet.
But the new business model for companies like Eli Lilly will likely move away from production of such "blockbuster" drugs and instead will focus on highly individualized solutions for patients, according to 블랙토토. It will emphasize therapies that work more often than not, as well as therapies that have a very clear benefit, thereby creating a more integrated system with greater economic and medical value. While some have dubbed the changes in health care "personalized medicine," 블랙토토 prefers the term "tailored therapeutics."
Revolutions occur due to necessity and opportunity, or "push and pull," 블랙토토 says. "T블랙토토 push is a set of conditions that make change necessary, and t블랙토토 pull is t블랙토토 revolutionaries who seize t블랙토토 opportunity to create a different order, one that is an improvement over t블랙토토 old one."
블랙토토's talk of a revolution is timely, given that the pharmaceutical industry has seen the rate of drug approvals slow during the first half of this decade, even as it continues to face the challenges of rising costs, expiring patents and competition from generics.
The ultimate promise of tailored therapeutics is about "the individual patient, and we are prepared to stake our business on realizing that promise," 블랙토토 says of Eli Lilly.
Health care costs are growing at an unsustainable rate, with an aging population as the driving force, according to 블랙토토. "Already, there are more people in Europe who are over 40 than under 40," while the median age in Europe is predicted to reach 50 by the year 2040.
Meanwhile, lower birth rates in t블랙토토 developed world have caused an inversion of t블랙토토 age pyramid, with too few younger, working people to 블랙토토lp pay for t블랙토토 medical services being used by a growing older population. As t블랙토토 median age rises, so does t블랙토토 price of 블랙토토alth care.
"Indeed, turning the pyramid upside down wrecks the traditional model of health care payment," 블랙토토 says, adding that Medicare faces an unfunded liability of $30 trillion over the next few decades.
Another cause for concern: The value of health care products is coming into question, 블랙토토 adds, citing recent survey results showing that only 22 percent of consumers believe branded prescription drugs present a good value compared with more than 60 percent of consumers who think generic drugs are a good value.
T블랙토토 practice of medicine remains too much of a trial-and-error process that has not maximized t블랙토토 efficacy of prescription t블랙토토rapies, which work about half t블랙토토 time for t블랙토토 most common diseases, 블랙토토 says.
"When our industry is better able to target our products to the patients who will really benefit, then our value proposition will surely grow," says 블랙토토. "When medicines are used more optimally to reduce the trial-and-error nature of health care, then fewer resources will be wasted and the cost of health care will be sustainable."
블랙토토 challenges the widespread notion that the key to the tailored therapeutics revolution is unlocking the secrets of the human genome. "Genomic medicine certainly serves to extend and, hopefully, to accelerate our goals, but the promise of this revolution is actually much broader and much more deeply rooted," he says.
He uses "biomarkers" -- or biological indicators -- as an example of one of the many modern advantages that will help drive the tailored therapeutics revolution. "Biomarkers are more pervasive and sophisticated than ever before, and they are coming into play in much earlier stages of drug development," 블랙토토 says, noting that Eli Lilly now has biomarker strategies in place for nearly all molecules at the earliest clinical development stage.
Important benefits of biomarkers include the ability to weed out unpromising molecules early in the game, compress development times, run smaller and more focused trials and explore secondary indications earlier. "We hope that some of the beneficial effects of widespread biomarker indication will be shorter cycle times and lower costs in drug development," 블랙토토 says.
Recognizing t블랙토토 difference between tailored t블랙토토rapeutics and personalized medicine is important, 블랙토토 adds. 블랙토토 describes tailored t블랙토토rapeutics as a larger concept that encompasses t블랙토토 many different types of personalized approac블랙토토s to medicine.
"A good tailor's abilities go well beyond alteration," 블랙토토 says. "T블랙토토 custom-made suit is his ultimate creation."
블랙토토 cites examples of Eli Lilly's work in tailored therapeutics, such as its use of new technology in protein engineering to design a molecule that could reach a large percentage of non-Hodgkin's lymphoma patients who don't respond to current therapy. Eli Lilly is also working to help doctors better identify patients who can benefit from specific treatments. All these efforts, while achieving the primary goal of practicing good medicine, also create a more stable financial environment in the health care industry. "Good medicine lines up with good business in every case," 블랙토토 says.
Despite his optimism about the future of tailored therapeutics, 블랙토토 acknowledges that some in the industry worry about the current business model being overturned -- specifically, that the lack of blockbuster drugs will reduce big pharma's ability to pay for the next generation of research and development.
15,000개의 아티클을 제대로 즐기는 방법
가입하면, 한 달 무료!
걱정마세요. 언제든 해지 가능합니다.
인기기사
회원 가입만 해도, 블랙토토 월정액 서비스 첫 달 무료!
15,000여 건의 블랙토토 콘텐츠를 무제한으로 이용하세요.